Every year, approximately 2 million women in the United States enter menopause. Most of these women will experience a wide variety of symptoms related to fluctuating or declining levels of estrogen, progesterone, follicle-stimulating hormone, and luteinizing hormone. For instance, approximately 80% of these women will experience vasomotor symptoms (VMS) at some point during perimenopause to postmenopause. Research has shown that VMS can cause substantial emotional and physical distress, and that approximately 60% of women will seek help from a healthcare practitioner to alleviate these symptoms. By tradition, hormone therapy (HT) has been widely and effectively used to treat VMS. However, some women may prefer not to use HT or they may not be good candidates for its use. The purpose of this article is to provide nurse practitioners with an overview of alternative (non-HT) methods discussed in the literature for the treatment of VMS. NPs can then provide VMS sufferers with information, education, guidance, and referrals regarding alternative treatment modalities so that these women can aim to achieve adequate symptom relief.