Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic disorder affecting 4%-10% of females. Females with PCOS usually present with multiple problems, including infertility, oligomenorrhea, and signs of hyperandrogenism. PCOS is also associated with major metabolic and cardiovascular disease risk factors. Nurse practitioners need to use varied approaches with female patients of different ages because of the different clinical, hormonal, and metabolic features related to PCOS that manifest at different times of life. Treating PCOS early reduces complications such as diabetes mellitus and heart disease later on. This article describes the presentation of PCOS across the lifespan and offers suggestions for management at different times in the life cycle.